The Musaro's Team

Cerimony for Sapienza Ricerca 2009 Award

Members of the Unit of Histology and Medical Embryology

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Science & Friends

Schematic model outlining the different phases of muscle regeneration. Muscle regeneration occurs in five interrelated and time dependent phases (text in blue). The necrosis of muscle fibers activates a transient muscle inflammation, which is necessary for the removal of necrotic cellular debris. Inflammation is followed by a regeneration phase that is characterized by the activation of stem cell populations (satellite cells and other nonmuscle stem cells), which replace damaged myofibers. The fourth phase involves the remodeling of extracellular matrix and angiogenesis. The muscle regeneration is completed by the reinnervation of regenerating fibers (From Musarò, Advances in Biology 2014, http://dx.doi.org/10.1155/2014/612471)

The molecular signature of satellite cells. Satellite cells express specific markers during the different stages of muscle regeneration. The text in blue indicates the molecular markers activated by satellite cells; the text in green indicates the molecular markers that are upregulated by satellite cells; the text in red indicates the markers that are downregulated by satellite cells in a specific stage of differentiation  (From Musarò, Advances in Biology 2014, http://dx.doi.org/10.1155/2014/612471)